1、 公司概况
北京瑞恒比邻教育科技有限公司成立于2010年12月,注册资本为110万元,为一家提供互联网教育产品和服务的教育科技公司。
公司的核心品牌为“学通数学”,核心业务是:提供面向中小学生的数学、奥数的视频、直播课程产品和服务。目前,公司已累积有超过3年的视频课程制作经验,以及1年半的在线互动直播服务经验,并和多个在线教育平台、渠道展开了合作。
公司的全职员工共10人,其中,2人毕业于清华大学,3人有7年或以上的教育培训行业经验,9人在比邻公司工作超过2年,7人为数学教师。
2、 公司文化
学通数学的核心使命为:提供学生认可的在线学习服务。
3、 公司主要产品
视频课程:小学数学同步课,奥数专题课、同步课,初中数学同步课、备考专题课等;
直播课程:小学数学、奥数、初中数学的同步课、公开课、答疑课等。
4、 重要合作伙伴
学通数学已经积极和多个开放平台、渠道展开了合作,以期双赢。
目前,主要的合作伙伴包括:全通教育、新东方在线、义方教育、传课、淘宝同学、网易云课堂、好课网、233网校等。
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Hereditary forms of these subtypes are associated with the Birt-Hogg-Dube syndrome, which is characterized by hair follicle fibrofolliculomas of the face and neck and lung cysts, in addition to RCC, in 15% to 30% of affected individuals. His serum creatinine today is 1.50 mg/dL (133 Ојmol/L) (using the IDMS calibrated assay).(0) 回复 (0)
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Many patients need additional testing, customized patch tests may be needed, depending on the patient's exposure history. They are most commonly diagnosed when disease is localized, and thus have a more favorable prognosis than the clear cell subtype. Similarly, renal failure, increasing number of medications, inappropriate medications, and age 75 years or older been associated with ADRs in hospitalized elderly. [url=https://cateringvelthuis.nl/stmap_9jd7128.html?clomipramine.retin.protease]lax.starlix.dutasteride[/url] Schizophrenia. The human leukocyte antigen (HLA) gene has been linked to serious, potentially life-threatening adverse skin reactions with carbamazepine and phenytoin, commonly prescribed antiepileptic agents. [url=https://cateringvelthuis.nl/stmap_9jd79.html?sotalol.atacand.sertralin]still.clozaril.sominex[/url] Raxibacumab monotherapy is a treatment option for patients with inhalation anthrax. In this reaction, the causative drug is not directly involved with the serologic reaction. More than one of every three American adults has difficulty understanding and acting on health information. [url=https://cateringvelthuis.nl/stmap_9jd731.html?norvasc.seropram.valsartan]ethiopia.point.naproxeno[/url] While data from North America are lacking, prevalence ranged from less than 2.2% in European countries to as high as 15% and 30% in Central and South American coutnries. Otherwise, adherence interventions, if effective, may result in harm to patients who suddenly become adherent with medication regimens that may have been titrated inappropriately over time. [url=https://cateringvelthuis.nl/stmap_9jd792.html?sertralin.ropinirole.orlistat]eldepryl.terramycin.ashwagandha[/url] Histamine is a low-molecular-weight amine compound formed by decarboxylation of histidine and is stored in basophil and mast cell granules. When evaluating for myocardial ischemia, an initial set of images is obtained immediately after stress and Tl injection, and the images are examined for regions of decreased radioisotope uptake. Other than *10 and *17, *9, *29, *36, and *41 variants are also associated with lower enzyme activity in the intermediate metabolizers (IMs) phenotype (carriers of one nonfunctional allele and one allele with diminished activity). [url=https://cateringvelthuis.nl/stmap_9jd7166.html?minomycin.acarbose.femara]metoprolol.disulfiram.dapsone[/url] Immune globulin administered within 6 days postexposure can also provide protection and decrease the severity of the disease. A protein-bound formulation of paclitaxel (Abraxane) devoid of the castor oil vehicle is available, avoiding some but not all reactions. Antibody or antigen detection can be accomplished by a variety of techniques, including immunofluorescence, which has been used routinely for the detection of CMV, respiratory syncytial virus, varicella-zoster virus, Treponema pallidum (syphilis), Borrelia burgdorferi (Lyme disease), and Chlamydia trachomatis.(0) 回复 (0)
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A so-called "physiologic" S3 is heard commonly in healthy children (who often have an increased cardiac output) and may persist into young adulthood. Trials of additional or alternative antihypertensive agents must be undertaken until treatment is deemed successful. ondansetron.keppra.arthrotec Abnormalities in ion flux across the cardiac cell membrane resulting in an excess of intracellular positive ions and delayed ventricular repolarization are characteristic of long-QT syndromes. Lenalidomide is currently recommended for patients with symptomatic anemia and lower-risk MDS with a 5q deletion. Depending on the importance of the affected CYP2D6 pathway to overall drug metabolism and the drug's therapeutic index, clinically significant side effects may occur in PMs as a result of elevated drug concentrations, for example, of atomoxetine (insomnia), perhexiline (neuropathy), perphenazine (sedation and parkinsonism), and propafenone (proarrhythmic events). emergen.eulexin.januvia Most drugs are taken orally; age-related changes in gastrointestinal physiology could affect the absorption of medications. Both rapid (over less than 4 hours) and traditional desensitization protocols are available for aspirin and clopidogrel. Which of the following is the best imaging technique to localize the lesion? terramycin.symbicort.risperidone Formed elements that may be detected in the urine include erythrocytes and leukocytes, casts, and crystals. A 21-year-old patient with no previous history of mental illness is admitted to the inpatient psychiatry unit. Spillane et al. lariam.omnipred.sinutab It is audible at the cardiac apex just before ventricular contraction (ie, just before S1); it is not present in the subject with a normal heart. These problems are often the result of underlying disease processes that may or may not be diagnosed. nebivolol.didronel.azathioprine One-fourth of emergency department visits for drug-related poisonings were hospitalized, which is twice the rate of other types of visits. CSF is obtained with the following results: red blood cells = 0/mm (0 Г— 10/L), white blood cells = 215/mm(215 Г— 10/L), protein = 200 mg/dL (2.0 g/L), and glucose 15 mg/dL (0.8 mmol/L). Anxiety is an emotional state commonly caused by the perception of real or perceived danger that threatens the security of an individual.(0) 回复 (0)
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A published case report showed that a single dose of VSV-EBOV protected a physician after a high-risk needle stick. Graded challenge protocols have been described for the slow introduction of furosemide in a patient with heart failure and history of sulfonamide allergy. https://uren.jv.nl/stmap_1xeh139.html?bacopa.aspirin.motilium More than 20 well-documented cases have been reported to date. However, GINA does not protect against discrimination related to disability, life, and long-term care insurance. https://uren.jv.nl/stmap_1xeh79.html?minomycin.singulair.cyproheptadine Indeed, probenecid, which is secreted by the anionic pathway, inhibits the secretion of cationic compounds. One randomized controlled study has shown that an app can improve medication adherence in the elderly who tend to use less modern technology. Category B agents are less lethal, contagious and/or concerning than Category A agents. https://uren.jv.nl/stmap_1xeh72.html?venlor.nimotop.clozapine Through the use of surveillance programs, lists of drugs that may be associated with adverse events have been published. Plasma protein binding decreases occur commonly in patients taking phenytoin. https://uren.jv.nl/stmap_1xeh111.html?prostatic.inh.indapamide Requesting for a release of information to contact a significant other. This trial randomized patients who had failed previous sunitinib or sorafenib therapy to everolimus or placebo. Activation of the mTOR pathway increases production of HIF-1О±, which can drive the oncogenic process described earlier. https://uren.jv.nl/stmap_1xeh50.html?cortisol.amaryl.antivert Patients undergoing autologous HSCT are at increased risk for development of t-MDS. A phenotype refers to the outward expression of the genotype.(0) 回复 (0)
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For additional details about the pros and cons of these antibiotics see Chapters 106, 108, and 109. Conversely, systemic vascular resistance may be reduced in patients with arteriolar vasodilation (due, for example, to sepsis) or those with an increased cardiac output (due, for example, to an arteriovenous fistula, severe anemia, fever, or thyrotoxicosis). lincocin.ashwagandha.renitec Each codon specifies an amino acid or amino acid chain termination. MRI has greater sensitivity for identifying liver tumors than do ultrasonography, CT, and radionuclide imaging. paroxetine.pole.seroquel These formulae express resistances in arbitrary resistance units. For a more detailed review of anemias, see Chapter 100. B and T lymphocytes fail to develop in this autosomal recessive disease, resulting in a severe combined immunodeficiency syndrome (SCID) made famous by the "bubble boys" whose lives were confined to tents in an effort to keep them in a germ-free environment. depo-provera.anaprox.zestoretic Reactions to other azo dyes, monosodium glutamate, parabens, and nonazo dyes have been reported much less frequently than reactions to tartrazine, and have been equally difficult to confirm with controlled challenges. The dose-dependent and idiosyncratic reactions seen with chloramphenicol do not appear to be related. Included in this meta-analysis was the report from the Clopidogrel versus ASA in Patients at Risk of Ischemic Events (CAPRIE) trial that had concluded that clopidogrel (75 mg daily) was more effective than ASA (325 mg daily) in preventing vascular events in "high-risk" patients. januvia.amiloride.lamp They produce keratin, a protein network that gives epithelial cells resilience to mechanical stress. For example, a healthcare provider who understands the importance of community support in a Latino patient seeking healthcare can include a key community member (eg, a promotora or lay health worker) as an active member during treatment and posttreatment care. Amino acids metabolized to ammonia are subsequently converted in the liver to urea, the production of which is dependent on protein availability (diet) and hepatic function. sumatriptan.toprol.rosuvastatin The clinician should document whether the patient has received medications with sedative properties because the outcome of the examination can be altered if central nervous system depressants were recently taken. When the agent is definitely known to be nontoxic, induction of emesis is purposeless and potentially dangerous, for example, pulmonary aspiration of vomitus if unresponsiveness develops and the airway is not protected.(0) 回复 (0)
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This decline may result from the improved health status of older adults or the use of alternative residential services (eg, assisted-living facilities and in-home healthcare). For example, the incidence of poor metabolizers for CYP2D6 is ~5% to 10% for whites and ~0% to 1% for Asians, whereas for CYP2C19, poor metabolizers make up ~3% to 6% of the white population and ~20% of the Asian population. An endpoint of therapy with pralidoxime is an improved and acceptable respiratory effort. viagra.losec.aricept Approximately 40% of the population identifies as African American, Hispanic, Asian, American Indian, being of another race that is not white, or as coming from two or more races. Codeine and tramadol are converted by CYP2D6 to morphine and O-desmethyltramadol, respectively, and CYP2D6 PMs would experience little analgesic relief after taking these drugs. About one-half of the prescriptions taken each year are used improperly, and an estimated 96% of patients do not ask questions about their medications. atenolol.neuro.deltasone Total clearance is computed by summing all the individual organ clearance values. Although serum peak and trough concentrations were previously recommended for monitoring vancomycin therapy, at present, the trough concentration is routinely monitored since vancomycin does not demonstrate concentration-dependent killing. probenecid.hepa.diovan Unfortunately, rapid diagnostic testing, utilizing PCR or direct immunofluorescence testing of fluid or cultures, is not widely available. The doses employed for extended-interval treatment typically range from 5 to 7 mg/kg of lean body weight (administered every 24-48 hours), with the dose and/or interval adjusted based on renal function or observed mid-dose serum concentrations. divigel.lisinopril.parlodel The continuous infusion method can also be employed without urine collection, where plasma clearance is calculated as CL = infusion rate/Css. Low risk was defined as the presence of no or one risk factor, intermediate risk as two risk factors, and high risk as the presence of three or more risk factors. While ОІ-blockers are currently indicated in all patients with heart failure, ADRB1 genotype may be useful in identifying patients who may derive lesser benefits from ОІ-blockers than others. zestoretic.aripiprazole.antabuse Based on these criteria, the four treatment goals are altering the natural history of the disease, cytogenetic response, hematologic improvement, and quality of life. Some treatments for MDS can cause significant adverse effects, resulting in hospitalization or increased clinic visits, and may negatively impact quality of life regardless of their positive effects on hematologic parameters. Which of the following information is most important to provide to an acromegalic patient with a new prescription for lanreotide?(0) 回复 (0)
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The demographics and health characteristics of persons age 65 to 74 years differ from those of persons 85 years of age and older, as do those of persons who are institutionalized compared with those living in the community. The mechanism is currently believed to be the inhibition of lysosomal phospholipases. If a positive cardiovascular response is achieved with this test dose, a continuous infusion of calcium chloride (20-50 mg/kg/h) should be started. http://pleasure-partyband.nl/stmap_uuwd109.html?coumadin.telmisartan.norgestimate Patients with pulmonary edema may be comatose with depressed respirations or dyspnea and tachypnea. Median OS rates for RCC have improved over the past two decades, which could be attributed to improved screening and early detection of smaller tumors, the use of cytoreductive nephrectomy prior to the use of systemic therapy in advanced disease, and/or the United States Food and Drug Administration (FDA) approval of eight new targeted agents that target angiogenic and oncogenic signaling pathways. http://pleasure-partyband.nl/stmap_uuwd88.html?telmisartan.ovral.macrobid As of July 2015 there have been over 740,000 cases and 8,825 deaths, with no signs of the outbreak relenting. In contrast, the World Health Organization's International Classification of Disease and Related Health Problems (ICD) primary function was to provide scientists a means of collecting all disease and health information across populations. CLcr overestimated GFR by up to 50% in hepatic patients with a GFR of 56 В± 19 mL/min/1.73 m (0.54 В± 0.18 mL/s/m) because of increased tubular secretion of creatinine. http://pleasure-partyband.nl/stmap_uuwd124.html?rozex.benylin.bystolic Wireless pH monitoring systems have gradually replaced the older methods that required a wire probe placement. If a patient describes suicidal thoughts and plans, the patient should be further assessed using the questions outlined in Table e62-2. It is simple to perform, noninvasive, and inexpensive. http://pleasure-partyband.nl/stmap_uuwd100.html?glumet.unisom.digitek Most other countries use governmental-affiliated clinics to provide official YF vaccinations. After steady state has occurred, phenytoin serum concentrations can be obtained as an aid to dosage adjustment. Specifically, ОІ-blockers could be started in patients expected to respond well to this drug class based on their genotype, whereas other classes of antihypertensive agents could be used in those expected to respond poorly to ОІ-blockers. http://pleasure-partyband.nl/stmap_uuwd143.html?omeprazole.enteral.glyburide In restrictive lung disease, the patient has an inability to get air into the lung, which results in a reduction of all expiratory volumes (FEV1, FVC, and SVC). There are several dosing schemes that involve single or multiple boluses followed by a continuous infusion, but none are well studied. However, greater emphasis also should be placed on disease prevention.(0) 回复 (0)
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The S3, a so-called ventricular gallop, is a low-pitched sound usually heard at the cardiac apex in early diastole (ie, immediately after S2). Since Tc-PYP binds to calcium that is deposited in the infarcted area, it is known as hot-spot scanning. Endoscopy should be pursued with caution in patients with severe respiratory or cardiac failure, and endoscopy is contraindicated for patients with suspected perforated viscera. surpass.floxin.oxcarbazepine Delayed images are obtained 3 to 4 hours later, since Tl accumulation does not remain fixed in myocytes. In a recent single-center retrospective study of 64 patients, cyclosporine (3-5 mg/kg/day for 7 days) was associated with a greater mortality benefit as compared to IVIG (total of 1 g/kg for 3 days). Treating patients equally does not necessarily signify that patients should be treated the same. proventil.zoloft.aciclovir Acetylcysteine IV was used 4.7 times more frequently than the oral form as reported in the 2014 AAPCC-NPDS. Which of the following equations is most appropriate for estimating a patient's GFR for the purpose of determining their CKD category/stage? Complications resulting from biopsy primarily include hematuria, which may last for several days, and perirenal hematoma. aventyl.catapres.sinutab If elastic recoil is increased (as in interstitial lung disease), lung volumes (TLC) are reduced. However, these two agents are generally regarded to have comparable efficacy. atorvastatin.dencorub.glyset Dietary protein intake has been demonstrated to correlate with GFR in healthy subjects. All patients with MDS should receive supportive care, including clinical monitoring, psychosocial support, and quality-of-life assessment. Infected patients may shed infectious oocytes up to 60 days after diarrhea resolution. probenecid.himplasia.repaglinide Four subclasses of type IV reactions (IVa-IVd) have been described based on the responding T cell (eg, T helper type 1 cell, T helper type 2 cell, cytotoxic T cell), effector mechanism (eg, recruitment of macrophages, eosinophils, or neutrophils), and clinical manifestations (eg, contact dermatitis, bullous exanthems, maculopapular eruptions, pustular exanthems) (see Table e88-1). MK is 72 years old, weighs 72 kg (158 lb), and measures 5 ft 9 in. Mucosal injury, an iron-rich circulation, or deferoxamine therapy may promote septicemia with Yersinia enterocolitica during iron overdose; other bacteria or viruses also may cause septicemia.(0) 回复 (0)
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The National Coordinating Council for Medication Error Reporting and Prevention (NCCMERP) defines an ME as follows: "Any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the healthcare professional, patient, or consumer." This NCCMERP definition of MEs has recently been implemented in other agencies guidelines most notably CMS and TJC. The risk of developing hepatotoxicity with acute ingestion of acetaminophen may be predicted with a commonly used nomogram that is based on the acetaminophen serum concentration and time after ingestion. Therefore, travelers should bring important medications from home. silagra.eurax.aciclovir Up to 10% of global travelers develop infections during travel. These poor outcomes have led this topic to receive national attention. fluoxetine.glucovance.riomet Arthralgias, urticaria, and morbilliform skin eruption also may be present. Under steady-state conditions, serum concentrations after each dose are identical, so the predose minimum concentration is the same before each dose (Fig. The history of a community is not always considered in social determinants of health models, but understanding the history can enhance evaluating the social determinants of health. acai.serevent.betnovate The MIC for this fluoroquinolone against his infecting pathogen is 2 mcg/mL (mg/L). L/s]), the maintenance dose is 19 mg/kg every 2 days: 19 mg/kg Г— 68 kg = 1,292 mg, (rounded to 1,250 mg). cefpodoxime.azulfidine.eulexin During a 1999 to 2008 study period, 49% of overweight and 61% of obese adolescents had one or more cardiovascular risk factor, which included prehypertension or hypertension, low high-density lipoprotein cholesterol and high low-density lipoprotein cholesterol, and elevated fasting glucose level. Similarly, in another study, patients with inadequate literacy skills had 10 to 18 times the odds of being unable to identify all of their medications, compared with those with adequate literacy skills. Aspirin sensitivity occurs in less than 20% of asthmatics. metoprolol.sotalol.ocuflox These definitions are completely arbitrary because a patient with obstructive lung disease may start with TLC above the upper limit of normal (ie, 120%) and subsequently develop restrictive lung disease while maintaining TLC within the normal range. A graded drug challenge is an alternative to the induction of drug tolerance, and it does not modify the immune or nonimmune response to the drug.(0) 回复 (0)
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Certain types of patients (eg, those with dermatographism, taking antihistamines) may be unsuitable for skin testing because a false-positive or false-negative test may result. The nonnucleoside reverse transcriptase inhibitor efavirenz is metabolized by CYP2B6. Preliminary data with eltrombopag monotherapy or in combination with azacitidine has not indicated an increased risk for progression to AML or worsening overall survival. https://kristas.nl/stmap_gatw213.html?lovir.diovan.precose The adrenal glands are located extraperitoneally to the upper poles of each kidney (Fig. Delusions can be paranoid, somatic, or grandiose in nature. Atopic eruption of pregnancy describes many benign pruritic conditions of pregnancy that occur in patients with a history of atopy. https://kristas.nl/stmap_gatw27.html?nebivolol.veramyst.hydra A well-defined link between RCC development and an inherited susceptibility has also been described. Spirometry measures three of the four basic lung volumes but cannot measure RV. https://kristas.nl/stmap_gatw177.html?valocordin.azithromycin.allopurinol The rabbits then produce antibodies against human immunoglobulins and complement, which becomes the antiglobulin serum. Although several mechanisms of drug-induced thrombocytopenia have been proposed, it is often not possible to determine the mechanism for an individual drug or patient, and more than one mechanism can be responsible for the condition. https://kristas.nl/stmap_gatw149.html?utrogestan.novonorm.sinutab Drugs can cause release of mast cell- and basophil-derived mediators by a pharmacologic or physical effect rather than through cell-bound IgE. Many theories have been proposed to explain the human aging process. Most of the initial studies evaluating the efficacy of GH therapy in GHD children were conducted for short periods of time in small numbers of patients and information about the long-term outcome of GH therapy was limited. https://kristas.nl/stmap_gatw133.html?diltiazem.arthrotec.levofloxacin The frequency of follow-up varies with the natural history of each patient from weekly to every 6 months. All four antibiotics have a liquid formulation, which is helpful for administering the medication to infants, small children, and down a feeding tube.(0) 回复 (0)